2,5-dimethyl Celecoxib
Code | Size | Price |
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TAR-T35610-1mg | 1mg | £148.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T35610-5mg | 5mg | £229.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T35610-10mg | 10mg | £334.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T35610-25mg | 25mg | £508.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T35610-50mg | 50mg | £701.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T35610-100mg | 100mg | £938.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
2,5-dimethyl Celecoxib is a celecoxib derivative and a targeted inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1), a key enzyme in the PGE2 synthesis pathway of inflammatory mediators.
CAS:
457639-26-8
Formula:
C18H16F3N3O2S
Molecular Weight:
395.4
Pathway:
GPCR/G Protein; Apoptosis; Immunology/Inflammation; Stem Cells; Cytoskeletal Signaling
Purity:
0.98
SMILES:
Cc1ccc(C)c(c1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F
Target:
Apoptosis; Wnt/beta-catenin; Prostaglandin Receptor
References
Chen Z, et al. 2,5-dimethylcelecoxib improves immune microenvironment of hepatocellular carcinoma by promoting ubiquitination of HBx-induced PD-L1. J Immunother Cancer. 2020 Oct;8(2):e001377.
Majchrzak-Celi?ska A, et al. COXIBs and 2,5-dimethylcelecoxib counteract the hyperactivated Wnt/?-catenin pathway and COX-2/PGE2/EP4 signaling in glioblastoma cells. BMC Cancer. 2021 May 3;21(1):493.
Egashira I, et al. Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/?-catenin signaling pathway. Cancer Sci. 2017 Jan;108(1):108-115.
Yamamoto M, et al. Cardiac and renal protective effects of 2,5-dimethylcelecoxib in angiotensin II and high-salt-induced hypertension model mice. J Hypertens. 2021 May 1;39(5):892-903.