2'2'-cGAMP (sodium salt)
| Code | Size | Price |
|---|
| TAR-T35654-1mg | 1mg | £806.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
2'2'-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds. It binds to the adapter protein stimulator of interferon genes , which is a component of the innate immune response that activates the type I interferon pathway when bound to cyclic dinucleotides. 2'2-cGAMP shows weaker binding to STING than 2'3'-cGAMP but binds more strongly than 3'3'-cGAMP , cyclic di-GMP , or 3'2'-cGAMP, which bind in the micromolar range (Kds = 1.04, 1.21, or 1.61 μM, respectively). Despite weaker binding, 2'2'-cGAMP induces IFN-β production in the same concentration range as 2'3'-cGAMP (EC50s = 15.8 and 19.4 nM, respectively, in L929 cells).
CAS:
1465774-27-9
Formula:
C20H24N10O13P2?2Na
Molecular Weight:
720.4
Purity:
0.98
SMILES:
O=P(OC[C@](O[C@H]1N2C=NC3=C2NC(N)=NC3=O)([H])C(O)[C@@]1([H])O4)(O)O[C@]([C@H](N5C=NC6=C5N=CN=C6N)O7)([H])C(O)[C@@]7([H])COP4(O)=O.[Na+].[Na+]