Myceliothermophin E

TargetMol
Product Code: TAR-T35690
Supplier: TargetMol
CodeSizePrice
TAR-T35690-1mg1mg£375.00
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Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Further Information

Bioactivity:
Myceliothermophin E is a polyketide-amino acid hybrid fungal metabolite that has been found inT. thermophilusand has anticancer and antimicrobial activities.1,2It is cytotoxic to DLD-1, Hep3B, HepG2, and HGC-27 cancer cells (IC50s = 0.32, 0.42, 0.26, and 0.08 μg/ml, respectively).1Myceliothermophin E is active against methicillin-resistant, but not -sensitive,S. aureus(MICs = 15.8 and >100 μM, respectively).2
CAS:
955083-90-6
Formula:
C26H37NO2
Molecular Weight:
395.6
Purity:
0.98
SMILES:
CC1=C[C@]2(C)C[C@H](C)CC[C@@]2([H])[C@H](C(C(C(N/3)=O)=CC3=CC(C)C)=O)[C@@H]1/C(C)=C/C

References

Wang, X., Zhao, L., Liu, C., et al.New tetramic acids comprising of decalin and pyridones from Chaetomium olivaceum SD-80A with antimicrobial activityFront. Microbiol.102958(2020) Gao, Y.-L., Zhang, M.-L., Wang, X., et al.Isolation and characterization of a new cytotoxic polyketide-amino acid hybrid from Thermothelomyces thermophilus ATCC 42464Nat. Prod. Res.Epub ahead of print(2019)