Violacein
| Code | Size | Price |
|---|
| TAR-T35751-1mg | 1mg | £936.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Violacein is a bacterial metabolite originally isolated from C. violaceum that has antibacterial and antiprotozoal activities.[1] [2] It is produced by C. violaceum as a purple pigment in response to N-hexanoyl homoserine lactone , a property that has been modified to create a strain of C. violaceum used in detecting quorum-sensing molecules.[3] Violacein is active against Gram-positive bacteria, including B. subtilis and S. aureus (MICs = 0.8 and 1.6 µM, respectively). It is also active against P. falciparum, including chloroquine-susceptible and -resistant strains (IC50s = 0.85 and 0.63 µM, respectively).[2] It reduces parasitemia in a mouse model of nonlethal P. chabaudi chabaudi infection when administered at a dose of 7.5 mg/kg and increases survival in a mouse model of lethal P. chabaudi chabaudi infection. Violacein permeabilizes the cytoplasmic membrane of bacterial cells but does not affect the cell wall.[1]
CAS:
548-54-9
Formula:
C20H13N3O3
Molecular Weight:
343.342
Purity:
0.98
SMILES:
Oc1ccc2[nH]cc(C3=CC(C(=O)N3)=C3/C(=O)Nc4ccccc34)c2c1
References
Blosser, R.S., and Gray, K.M. Extraction of violacein from Chromobacterium violaceum provides a new quantitative bioassay for N-acyl homoserine lactone autoinducers. J. Microbiol. Methods 40(1), 47-55 (2000).
Cauz, A.C.G., Carretero, G.P.B., Saraiva, G.K.V., et al. Violacein targets the cytoplasmic membrane of bacteria. ACS Infect. Dis. 5(4), 539-549 (2019).
Lopes, S.C.P., Blanco, Y.C., Justo, G.Z., et al. Violacein extracted from Chromobacterium violaceum inhibits Plasmodium growth in vitro and in vivo. Antimicrob. Agents Chemother. 53(5), 2149-2152 (2009).