TargetMol

Pirtobrutinib

Product Code:
 
TAR-T36287
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36287-1mg1mg£95.00
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TAR-T36287-5mg5mg£128.00
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TAR-T36287-1mL1 mL * 10 mM (in DMSO)£132.00
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TAR-T36287-10mg10mg£173.00
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TAR-T36287-25mg25mg£309.00
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TAR-T36287-50mg50mg£438.00
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TAR-T36287-100mg100mg£610.00
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TAR-T36287-500mg500mg£1,219.00
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Further Information

Bioactivity:
Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor. Pirtobrutinib inhibits diverse BTK C481 substitution mutations. Pirtobrutinib causes regression of BTK-dependent lymphoma tumors in mouse xenograft models. Pirtobrutinib is also more than 300-fold selective for BTK versus 370 other kinases tested and shows no significant inhibition of non-kinase off-targets at 1 μM.
CAS:
2101700-15-4
Formula:
C22H21F4N5O3
Molecular Weight:
479.43
Pathway:
Tyrosine Kinase/Adaptors; Angiogenesis
Purity:
0.9989
SMILES:
N/A
Target:
BTK

References

Gomez E B , et al. Loxo-305, a Highly Selective and Non-Covalent Next Generation BTK Inhibitor, Inhibits Diverse BTK C481 Substitution Mutations[J]. Blood, 2019, 134(Supplement_1):4644-4644.