TargetMol

Sydowinin B

Product Code:
 
TAR-T36355
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T36355-1mg1mg£741.00
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Further Information

Bioactivity:
Sydowinin B is a xanthone polyketide that has been found inA. sydowiiand has immunosuppressant activity.1It inhibits LPS- or concanavalin A-induced proliferation of isolated mouse splenic lymphocytes (IC50s = 19.2 and 20.8 μg/ml, respectively).2Sydowinin B inhibits superoxide generation in, and elastase release from, isolated human neutrophils induced by cytochalasin B and N-Formyl-Met-Leu-Phe with IC50values of 21.2 and 12.62 μM, respectively.3
CAS:
58450-00-3
Formula:
C16H12O7
Molecular Weight:
316.265
Purity:
0.98
SMILES:
COC(=O)c1c(O)ccc2oc3cc(CO)cc(O)c3c(=O)c12

References

Hamasaki, T., Sato, Y., and Hatsuda, Y.Structure of sydowinin A, sydowinin B, and sydowinol, metabolites from Aspergillus sydowiAgr. Biol. Chem.39(12)2341-2345(1975) Chung, Y.-M., Wei, C.-K., Chuang, D.-W., et al.An epigenetic modifier enhances the production of anti-diabetic and anti-inflammatory sesquiterpenoids from Aspergillus sydowiiBioorg. Med. Chem.21(13)3866-3872(2013) Liu, H., Chen, S., Liu, W., et al.Polyketides with immunosuppressive activities from mangrove endophytic fungus Penicillium sp. ZJ-SY2Mar. Drugs14(12)217(2016)