Urdamycin A
| Code | Size | Price |
|---|
| TAR-T36477-1mg | 1mg | £225.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Urdamycin A is a bacterial metabolite originally isolated fromS. fradiaethat has antibacterial and anticancer activities.1,2It is active against a variety of Gram-positive and Gram-negative bacteria, includingB. subtilisand strains ofArthrobacterandStreptomyces, but not the fungusS. cerevisiae, in a disc assay when used at a concentration of 1 mg/ml.2Urdamycin A is cytotoxic to L1210 and HT-29, but not A549, cancer cells (IC50s = 7.5, 5, and >10 μg/ml, respectively).1
CAS:
98474-21-6
Formula:
C43H56O17
Molecular Weight:
844.9
Purity:
0.98
SMILES:
O[C@@H]1C[C@H](O[C@H]2CC[C@H](O[C@H]3[C@H](O)[C@@H](C)O[C@](C4=C(O)C(C(C(C=C[C@@](C[C@](O)(C)C5)(O)[C@]6(O[C@H]7CC[C@H](O)[C@H](C)O7)C5=O)=C6C8=O)=O)=C8C=C4)([H])C3)O[C@H]2C)O[C@H](C)[C@H]1O
References
Drautz, H., Z?hner, H., Rohr, J., et al.Metabolic products of microorganisms. 234. Urdamycins, new angucycline antibiotics from Streptomyces fradiae. I. Isolation, characterization and biological propertiesJ. Antibiot. (Tokyo)39(12)1657-1669(1986)
Henkel, T., Ciesiolka, T., Rohr, J., et al.Urdamycins, new angucycline antibiotics from Streptomyces fradiae. V. Derivatives of urdamycin AJ. Antibiot. (Tokyo)42(2)299-311(1989)