GDC0084

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TargetMol
Product Code: TAR-T3705
Supplier: TargetMol
CodeSizePrice
TAR-T3705-1mg1mg£114.00
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TAR-T3705-2mg2mg£124.00
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TAR-T3705-1mL1 mL * 10 mM (in DMSO)£169.00
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TAR-T3705-5mg5mg£169.00
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TAR-T3705-10mg10mg£230.00
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TAR-T3705-25mg25mg£397.00
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TAR-T3705-50mg50mg£495.00
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TAR-T3705-100mg100mg£683.00
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TAR-T3705-500mg500mg£1,348.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
GDC-0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity. GDC-0084 specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in the inhibition of both cell growth and survival in susceptible tumor cell populations.
CAS:
1382979-44-3
Formula:
C18H22N8O2
Molecular Weight:
382.428
Pathway:
PI3K/Akt/mTOR signaling
Purity:
0.9916
SMILES:
CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CCOCC1
Target:
PI3K; mTOR

References

Heffron TP, et al. ACS Med Chem Lett. 2016, 7(4):351-6. Salphati L, et al. Drug Metab Dispos. 2016, 44(12):1881-1889.