M62812

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TargetMol
Product Code: TAR-T37292
Supplier: TargetMol
CodeSizePrice
TAR-T37292-1mg1mg£95.00
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TAR-T37292-5mg5mg£128.00
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TAR-T37292-1mL1 mL * 10 mM (in DMSO)£156.00
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TAR-T37292-10mg10mg£161.00
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TAR-T37292-25mg25mg£265.00
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TAR-T37292-50mg50mg£401.00
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TAR-T37292-100mg100mg£550.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
TLR4 inhibitor. Inhibits LPS-induced NF-κB activation in HEK293 cells (IC50 = 2.4 μg/mL). Also inhibits LPS-induced cytokine production and procoagulant effects in PBMCs and HUVECs. Prolongs survival in a mouse septic shock model.
CAS:
613263-00-6
Formula:
C13H13Cl2N3OS
Molecular Weight:
330.23
Pathway:
Immunology/Inflammation
Purity:
0.98
SMILES:
Cl.Cl.Nc1nsc2cc(Oc3ccccc3N)ccc12
Target:
TLR

References

Masaki Nakamura, et al. Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice. Eur.J.Pharmacol. 569 237 PMID:17588563