JKE-1674

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TargetMol
Product Code: TAR-T37314
Supplier: TargetMol
CodeSizePrice
TAR-T37314-1mg1mg£109.00
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TAR-T37314-5mg5mg£161.00
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TAR-T37314-1mL1 mL * 10 mM (in DMSO)£181.00
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TAR-T37314-10mg10mg£217.00
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TAR-T37314-25mg25mg£369.00
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TAR-T37314-50mg50mg£550.00
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Quantity:
TAR-T37314-100mg100mg£838.00
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TAR-T37314-200mg200mg£1,099.00
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TAR-T37314-500mg500mg£1,589.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210.
CAS:
2421119-60-8
Formula:
C20H20Cl2N4O4
Molecular Weight:
451.3
Pathway:
oxidation-reduction
Purity:
0.98
SMILES:
O=C(C(C[N+]([O-])=O)=NO)N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1
Target:
GPX

References

Eaton JK, et al. Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles. Nat Chem Biol. 2020;16(5):497-506. Kathman SG, et al. A masked zinger to block GPX4. Nat Chem Biol. 2020;16(5):482-483.