Tryptoquivaline D
| Code | Size | Price |
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| TAR-T37584-1mg | 1mg | £786.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Tryptoquivaline D is a fungal metabolite that has been found inNeosartorya siamensisand has anticancer activity.1,2It induces nuclear chromatin condensation, a marker of apoptosis, in HCT116 colon and HepG2 liver cancer cells when used at a concentration of 150 μM.1Tryptoquivaline D (1-100 μM), alone or in combination with doxorubicin , reduces the viability of A549 lung cancer cells.2
CAS:
60676-56-4
Formula:
C28H28N4O7
Molecular Weight:
532.553
Purity:
0.98
SMILES:
CC(C)[C@@H](OC(C)=O)c1nc2ccccc2c(=O)n1[C@H]1C[C@]2(OC1=O)[C@H]1N(O)[C@H](C)C(=O)N1c1ccccc21
References
Prata-Sena, M., Ramos, A.A., Buttachon, S., et al.Cytotoxic activity of secondary metabolites from marine-derived fungus Neosartorya siamensis in human cancer cellsPhytother. Res.30(11)1862-1871(2016)
Ramos, A.A., Castro-Carvalho , B., Prata-Sena, M., et al.Can marine-derived fungus Neosartorya siamensis KUFA 0017 extract and its secondary metabolites enhance antitumor activity of doxorubicin? An in vitro survey unveils interactions against lung cancer cellsEnviron. Toxicol.35(4)507-517(2020)