3'-sulfo Galactosylsphingosine (ammonium salt)
| Code | Size | Price |
|---|
| TAR-T38090-1mg | 1mg | £858.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
3'-sulfo Galactosylsphingosine is a form of sulfatide that is lacking the fatty acyl group. It decreases migration and adhesion of B35 neuroblastoma cells and increases cell rounding when used at a concentration of 20 μM. It also inhibits PKC and cytochrome c oxidase activity when used at concentrations of 150 and 50-100 μM, respectively. 3'-sulfo Galactosylsphingosine accumulates in patients with metachromatic leukodystrophy, a lysosomal storage disorder characterized by arylsulfatase A (ASA) deficiency leading to progressive demyelination and neuromotor deficits. In mice lacking ASA, levels of 3'-sulfo galactosylsphingosine increase after one month of age followed by demyelination and neuromotor deficits. 3'-sulfo Galactosylsphingosine has been used as a standard for the quantification of 3'-sulfo galactosylsphingosine by LC-MS.
CAS:
1246681-32-2
Formula:
C24H46NO10S?NH4
Molecular Weight:
558.7
Purity:
0.98
SMILES:
O[C@@H]1[C@@H](OS([O-])(=O)=O)[C@@H](O)[C@@H](CO)O[C@H]1OC[C@H](N)[C@H](O)/C=C/CCCCCCCCCCCCC.[NH4+]