NF-κB Inhibitor (trifluoroacetate salt)
| Code | Size | Price |
|---|
| TAR-T38153-1mg | 1mg | £197.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T38153-5mg | 5mg | £610.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells.1It blocks the nuclear import of p105 in cells treated with activators of NF-κB signaling, including LPS and TNF-α.1In this way, NF-κB inhibitor blocks gene expression that is regulated by NF-κB.2,3This peptide is commonly used to evaluate the role of NF-κB signaling in cellular responses.4,5
CAS:
0
Formula:
0
Molecular Weight:
0
Purity:
0.98
SMILES:
0
References
Methot, L., Hermann, R., Tang, Y., et al.Interaction and antagonistic roles of NF-?B and Hes6 in the regulation of cortical neurogenesisMolecular and Cellular Biology33(14)2797-2808(2013)
Kasibhatla, S., Genestier, L., and Green, D.R.Regulation of fas-ligand expression during activation-induced cell death in T lymphocytes via nuclear factor ?BThe Journal of Biological Chemisty274(2)987-992(1999)
Lin, Y.Z., Tao, S., Veach, R.A., et al.Inhibition of nuclear translocation of transcription factor NF-?B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequenceJ. Biol. Chem.270(24)14255-14258(1995)
Torgerson, T.R., Colosia, A.D., Donahue, J.P., et al.Regulation of NF-?B, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization sequence of NF-?B p50Journal of Immunology161(11)6084-6092(1998)
W?ster, P., Rosdahl, I., and ?linger, K.Cell fate regulated by nuclear factor-?B- and activator protein-1-dependent signalling in human melanocytes exposed to ultraviolet A and ultraviolet BBritish Journal of Dermatology171(6)1336-1346(2014)