Lalistat 1

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TargetMol
Product Code: TAR-T38344
Supplier: TargetMol
CodeSizePrice
TAR-T38344-1mg1mg£99.00
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TAR-T38344-5mg5mg£132.00
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TAR-T38344-10mg10mg£156.00
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TAR-T38344-25mg25mg£206.00
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TAR-T38344-50mg50mg£269.00
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TAR-T38344-100mg100mg£362.00
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TAR-T38344-500mg500mg£772.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
Lalistat 1 is an inhibitor of lysosomal acid lipase (LAL, IC50 = 68 nM) and IgA1 protease for H. influenzae. Lalistat 1 can be used in studies about niemann-pick type C diseases.
CAS:
501104-16-1
Formula:
C12H18N4O3S
Molecular Weight:
298.36
Pathway:
Microbiology/Virology
Purity:
0.997
SMILES:
O=C(Oc1nsnc1N1CCCCC1)N1CCOCC1
Target:
Antibacterial

References

Rosenbaum, A.I., Rujoi, M., Huang, A.Y., et al. Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors. Biochim Biophys. Acta. 1791(12), 1155-1165 (2009). Rosenbaum, A.I., Cosner, C.C., Mariani, C.J., et al. Thiadiazole carbamates: Potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. J. Med. Chem. 53(14), 5281-5289 (2010). Livia Shehaj, et al. Small-Molecule Inhibitors of Haemophilus influenzae IgA1 Protease.ACS Infect Dis. 2019 Jul 12;5(7):1129-1138.