TargetMol

AWL-II-38.3

Product Code:
 
TAR-T38511
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T38511-1mg1mg£130.00
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TAR-T38511-5mg5mg£213.00
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TAR-T38511-1mL1 mL * 10 mM (in DMSO)£220.00
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TAR-T38511-10mg10mg£294.00
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TAR-T38511-25mg25mg£530.00
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TAR-T38511-50mg50mg£731.00
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TAR-T38511-100mg100mg£978.00
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TAR-T38511-500mg500mg£1,902.00
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Further Information

Bioactivity:
AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular activity against Src-family kinases nor against b-raf [1] [2].
CAS:
1135205-94-5
Formula:
C23H18F3N5O3
Molecular Weight:
469.42
Pathway:
Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
CC1=CN(C=N1)C1=CC(=CC(=C1)C(F)(F)F)C(=O)NC1=CC=C(C)C(NC(=O)C2=CC=NO2)=C1
Target:
Ephrin Receptor

References

Yongmun Choi, et al. Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4467-70. Efrat Mashiach-Farkash, et al. Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. Oncotarget. 2012 Jun;3(6):629-39.