Echinatin
| Code | Size | Price |
|---|
| TAR-T3926-1mL | 1 mL * 10 mM (in DMSO) | £159.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T3926-10mg | 10mg | £167.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T3926-20mg | 20mg | £191.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Echinatin disturb the mitochondrial energy transfer reactions and membrane permeability, at a low concentration cause deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria, inhibits DNP-ATPase activity while stimulating range latent ATPase activity. Echinatin has significant antioxidant activities, it shows strong scavenging activity toward the ABTS + radical, it also dose-dependently inhibits LPS induced reactive oxygen species (ROS) production in RAW 264.7 cells and inhibits the production of nitric oxide (NO), interleukin-6 (IL-6) and prostaglandin E2 (PGE2) in LPS-induced macrophage cells.
CAS:
34221-41-5
Formula:
C16H14O4
Molecular Weight:
270.284
Pathway:
oxidation-reduction
Purity:
0.9961
SMILES:
COc1cc(O)ccc1C=CC(=O)c1ccc(O)cc1
Target:
Free radical scavengers
References
Fu Y, et al. Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice.[J]. Food Chemistry, 2013, 141(2):1063-1071.
Inoue B, et al. The effects of echinatin and its related compounds on the mitochondrial energy transfer reaction.[J]. Journal of Toxicological Sciences, 1982, 7(4):245.
Yang X, Liu L, Hao Y, et al. An Ultrasensitive Biosensor for Quantifying the Interaction of SARS-CoV-2 and Its Receptor ACE2 in Cells and in vitro[J]. bioRxiv. 2020
Hong P, Liu Q W, Xie Y, et al. Echinatin suppresses esophageal cancer tumor growth and invasion through inducing AKT/mTOR-dependent autophagy and apoptosis[J]. Cell Death & Disease. 2020, 11(7): 1-13.
Yang X, Liu L, Hao Y, et al. An Ultrasensitive Biosensor for Quantifying the Interaction of SARS-CoV-2 and Its Receptor ACE2 in Cells and in vitro. Viruses. 2021 Jun 2;13(6):1055. doi: 10.3390/v13061055.
Hong P, Liu Q W, Xie Y, et al. Echinatin suppresses esophageal cancer tumor growth and invasion through inducing AKT/mTOR-dependent autophagy and apoptosis. Cell Death & Disease. 2020, 11(7): 1-13