Desmorpholinyl Navitoclax-NH-Me

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TargetMol
Product Code: TAR-T39910
Supplier: TargetMol
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TAR-T39910-1mg1mg£182.00
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TAR-T39910-5mg5mg£349.00
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TAR-T39910-10mg10mg£535.00
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TAR-T39910-1mL1 mL * 10 mM (in DMSO)£541.00
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TAR-T39910-25mg25mg£820.00
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TAR-T39910-50mg50mg£1,091.00
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TAR-T39910-100mg100mg£1,428.00
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Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
Desmorpholinyl Navitoclax-NH-Me is a Bcl-xL inhibitor. Desmorpholinyl Navitoclax-NH-Me and a CRBN ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC BCL-XL degrader XZ739 [1] [2] .
CAS:
2365172-82-1
Formula:
C44H51ClF3N5O5S3
Molecular Weight:
918.55
Pathway:
Apoptosis
Purity:
0.98
SMILES:
CC(C)(CC1)CC(CN(CC2)CCN2c(cc2)ccc2C(NS(c(cc2)cc(S(C(F)(F)F)(=O)=O)c2N[C@H](CCNC)CSc2ccccc2)(=O)=O)=O)=C1c(cc1)ccc1Cl
Target:
BCL

References

Guangrong Zheng, et al. Agents de d?gradation de prot?ines bcl-2 pour le traitement du cancer. WO2019144117A1.