Diffractaic Acid
| Code | Size | Price |
|---|
| TAR-T4114-1mL | 1 mL * 10 mM (in DMSO) | £414.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T4114-20mg | 20mg | £661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Diffractaic Acid can inhibit LTB4 biosynthesis in A-23187-stimulated bovine PMNL cells with activity value of 8 μM.
CAS:
436-32-8
Formula:
C20H22O7
Molecular Weight:
374.389
Pathway:
Apoptosis; Immunology/Inflammation
Purity:
0.9981
SMILES:
COc1cc(C)c(C(=O)Oc2cc(C)c(C(O)=O)c(O)c2C)c(OC)c1C
Target:
Apoptosis; LTR
References
Kumar KC, et al. Lichen metabolites. 1. Inhibitory action against leukotriene B4 biosynthesis by a non-redox mechanism. J Nat Prod. 1999 Jun;62(6):817-20.
Kal?n ? N, Altay A, Budak H. Diffractaic acid, a novel TrxR1 inhibitor, induces cytotoxicity, apoptosis, and antimigration in human breast cancer cells. Chemico-Biological Interactions. 2022: 109984
Budak B, Kal?n ? N, Yap?a ? E.Antiproliferative, antimigratory, and apoptotic effects of diffractaic and vulpinic acids as thioredoxin reductase 1 inhibitors on cervical cancer.Naunyn-Schmiedeberg's Archives of Pharmacology.2023: 1-11.
G?nayd?n ?, Suluko?lu E K, Kal?n ? N, et al.Diffractaic acid exhibits thioredoxin reductase 1 inhibition in lung cancer A549 cells.Journal of Applied Toxicology.2023;1?10.