XMU-MP-1

TargetMol
Product Code: TAR-T4212
Supplier: TargetMol
CodeSizePrice
TAR-T4212-1mg1mg£109.00
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TAR-T4212-2mg2mg£128.00
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TAR-T4212-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T4212-5mg5mg£149.00
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TAR-T4212-10mg10mg£195.00
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TAR-T4212-25mg25mg£329.00
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TAR-T4212-50mg50mg£503.00
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TAR-T4212-100mg100mg£695.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

1 / 1

Further Information

Bioactivity:
XMU-MP-1 is an inhibitor of the pro-apoptotic, sterile 20-like kinases MST1 and 2.
CAS:
2061980-01-4
Formula:
C17H16N6O3S2
Molecular Weight:
416.47
Pathway:
Stem Cells
Purity:
0.9968
SMILES:
CN1c2ccsc2C(=O)N(C)c2cnc(Nc3ccc(cc3)S(N)(=O)=O)nc12
Target:
Hippo pathway

References

Xu W, Shi Z, Yu X, et al.Salvianolic acid B exerts an anti-hepatocellular carcinoma effect by regulating the Hippo/YAP pathway and promoting pSmad3L to pSmad3C simultaneously.European Journal of Pharmacology.2022: 175423. Yang L, Li N, Yang D, et al. CCL2 regulation of MST1-mTOR-STAT1 signaling axis controls BCR signaling and B-cell differentiation. Cell Death & Differentiation. 2021: 1-18 Shang Y, Yan Y, Chen B, et al. Over?expressed MST1 impaired spatial memory via disturbing neural oscillation patterns in mice[J]. Genes, Brain and Behavior. 2020: e12678. Fan F, et al. Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration. Sci Transl Med. 2016 Aug 17;8(352):352ra108. Wang H, Shang Y, Wang E, et al. MST1 mediates neuronal loss and cognitive deficits: A novel therapeutic target for Alzheimer?s disease. Progress in Neurobiology. 2022: 102280 Yang L, Li N, Yang D, et al. CCL2 regulation of MST1-mTOR-STAT1 signaling axis controls BCR signaling and B-cell differentiation[J]. Cell Death & Differentiation. 2021: 1-18. Zhu Y, Gu H, Yang L, et al. Involvement of MST1/mTORC1/STAT1 activity in the regulation of B-cell receptor signalling by chemokine receptor 2. Clinical and Translational Medicine. 2022, 12(7): e887. Shang Y, Yan Y, Chen B, et al. Over?expressed MST1 impaired spatial memory via disturbing neural oscillation patterns in mice. Genes, Brain and Behavior. 2020: e12678 Zhu Y, Gu H, Yang L, et al. The sequential role of Mst1/mTORC1/STAT1 activity in chemokine receptor 2-regulated B cell receptor signaling[J]. Authorea Preprints. 2021