CIL56

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TargetMol
Product Code: TAR-T4309
Supplier: TargetMol
CodeSizePrice
TAR-T4309-1mg1mg£95.00
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TAR-T4309-2mg2mg£106.00
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TAR-T4309-5mg5mg£128.00
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TAR-T4309-1mL1 mL * 10 mM (in DMSO)£133.00
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TAR-T4309-10mg10mg£164.00
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TAR-T4309-25mg25mg£230.00
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TAR-T4309-50mg50mg£324.00
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TAR-T4309-100mg100mg£458.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
CIL56 is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS). It also induces accumulation of long-chain saturated, monounsaturated, and polyunsaturated fatty acids in HT-1080 cells in vitro.HT-1080 cells lacking acetyl-CoA carboxylase 1 (ACC1), the rate-limiting enzyme in fatty acid synthesis, exhibit 5-fold resistance to CIL56 treatment, indicating ACC1 activity sensitizes cells to CIL56-induced cell death.
CAS:
300802-28-2
Formula:
C23H27N3O5S2
Molecular Weight:
489.61
Pathway:
Apoptosis; Immunology/Inflammation; Cell Cycle/Checkpoint
Purity:
0.9991
SMILES:
ON=C1c2cc(ccc2-c2ccc(cc12)S(=O)(=O)N1CCCCC1)S(=O)(=O)N1CCCCC1
Target:
Ferroptosis; ROS

References

Yang WS,etal.Ferroptosis: Death by Lipid Peroxidation.Trends Cell Biol. 2016 Mar;26(3):165-176. Li P, Lin Q, Sun S, et al. Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism. Cell Death & Disease. 2022, 13(9): 1-15. Dixon SJ,etal.Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death.ACS Chem Biol. 2015 Jul 17;10(7):1604-9. Shimada K,etal.Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis.Nat Chem Biol. 2016 Jul;12(7):497-503.