EOC317

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TargetMol
Product Code: TAR-T4318
Supplier: TargetMol
CodeSizePrice
TAR-T4318-1mg1mg£145.00
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TAR-T4318-2mg2mg£181.00
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TAR-T4318-5mg5mg£230.00
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TAR-T4318-1mL1 mL * 10 mM (in DMSO)£286.00
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TAR-T4318-10mg10mg£349.00
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TAR-T4318-25mg25mg£544.00
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TAR-T4318-50mg50mg£747.00
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TAR-T4318-100mg100mg£1,002.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
ACTB-1003 is an oral kinase inhibitor (IC50: 6/2/4 nM, for FGFR1/VEGFR2/Tie-2).
CAS:
939805-30-8
Formula:
C27H26F5N7O3
Molecular Weight:
591.543
Pathway:
Tyrosine Kinase/Adaptors; Angiogenesis
Purity:
0.99
SMILES:
COCc1c(CN2CCOCC2)n2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)c(F)c1
Target:
VEGFR; FGFR; Tie-2

References

Patel K, et al. ACTB-1003: An oral kinase inhibitor targeting cancer mutations (FGFR), angiogenesis (VEGFR2, TEK), and induction of apoptosis (RSK and p70S6K). Journal of Clinicalal Oncology 28, no. 15 DOI: 10.1200/jco.2010.28.15_suppl.e13665