AZ32

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TargetMol
Product Code: TAR-T4443
Supplier: TargetMol
CodeSizePrice
TAR-T4443-1mg1mg£111.00
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TAR-T4443-2mg2mg£130.00
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TAR-T4443-5mg5mg£168.00
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TAR-T4443-1mL1 mL * 10 mM (in DMSO)£177.00
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TAR-T4443-10mg10mg£229.00
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TAR-T4443-25mg25mg£349.00
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TAR-T4443-50mg50mg£506.00
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TAR-T4443-100mg100mg£699.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.
CAS:
2288709-96-4
Formula:
C20H16N4O
Molecular Weight:
328.37
Pathway:
PI3K/Akt/mTOR signaling; DNA Damage/DNA Repair
Purity:
0.9994
SMILES:
CNC(=O)c1ccc(cc1)c2cnc3cnc(cn23)c4ccccc4
Target:
ATM/ATR

References

Karlin J, et al. Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice. Mol Cancer Ther. 2018 Aug;17(8):1637-1647. Liu K, Li Y C, Chen Y, et al. AZ32 reverses ABCG2-mediated multidrug resistance in colorectal cancer. Frontiers in Oncology. 2021, 11: 1764. Liu K, Li Y C, Chen Y, et al. AZ32 reverses ABCG2-mediated multidrug resistance in colorectal cancer[J]. Frontiers in Oncology. 2021, 11: 1764.