Lazertinib

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TargetMol
Product Code: TAR-T4485
Supplier: TargetMol
CodeSizePrice
TAR-T4485-1mg1mg£103.00
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TAR-T4485-2mg2mg£118.00
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TAR-T4485-5mg5mg£145.00
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TAR-T4485-1mL1 mL * 10 mM (in DMSO)£160.00
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TAR-T4485-10mg10mg£193.00
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TAR-T4485-25mg25mg£289.00
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TAR-T4485-50mg50mg£346.00
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TAR-T4485-100mg100mg£470.00
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TAR-T4485-500mg500mg£994.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Lazertinib is an effective, highly mutant-selective and irreversible EGFR-TKI with IC50 values of 1.7 nM, 2 nM, 5 nM, 20.6 nM and 76 nM for Del19/T790M, L858R/T790M, Del19, L85R and Wild type EGFR respectively.
CAS:
1903008-80-9
Formula:
C30H34N8O3
Molecular Weight:
554.655
Pathway:
Tyrosine Kinase/Adaptors; Angiogenesis; JAK/STAT signaling
Purity:
0.9996
SMILES:
COc1cc(N2CCOCC2)c(NC(=O)C=C)cc1Nc1nccc(n1)-n1cc(CN(C)C)c(n1)-c1ccccc1
Target:
EGFR

References

Byoung Chul Cho, et al. YH25448, a 3rd Generation EGFR-TKI, in Patients with EGFR-TKI-resistant NSCLC: Phase I/II Study Results.