Berberine
| Code | Size | Price |
|---|
| TAR-T4S0797-1mL | 1 mL * 10 mM (in DMSO) | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T4S0797-20mg | 20mg | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
1. Berberine is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism. 2. Berberine may as a broad-spectrum anti-microbial medicine, a complementary therapeutic agent for HIV/AIDS. 3. Berberine seems to act as an herbal antidepressant and a neuroprotector against neurodegenerative disorders. 4. Berberine is used in histology for staining heparin in mast cells. As a natural dye, berberine has a colour index of 7516. 5. Berberine reduces hepatic fat content in rats with nonalcoholic fatty liver disease; also prevents proliferation of hepatic stellate cells (HSCs), which are central for the development of fibrosis during liver injury. 6. Berberine can ameliorate proinflammatory cytokines-induced intestinal epithelial tight junction damage in vitro, and berberine may be one of the targeted therapeutic agents that can restore barrier function in intestinal disease states. 7. Berberine has antineoplastic effects, including breast cancer, leukemia, melanoma, epidermoid carcinoma, hepatoma, pancreatic cancer, oral carcinoma, tongue carcinoma, glioblastoma, prostate carcinoma and gastric carcinoma, etc.
CAS:
2086-83-1
Formula:
C20H18NO4+
Molecular Weight:
336.36
Pathway:
DNA Damage/DNA Repair; NF-κb; Immunology/Inflammation; Microbiology/Virology; Metabolism; Autophagy
Purity:
0.9877
SMILES:
COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC
Target:
Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy
References
Zhou Z, Lin Y, Gao L, et al. Circadian Pharmacological Effects of Berberine on Chronic Colitis in Mice: Role of the Clock Component Rev-erb?. Biochemical Pharmacology. 2020, 172: 113773.
Zhou Z, Lin Y, Gao L, et al. Circadian Pharmacological Effects of Berberine on Chronic Colitis in Mice: Role of the Clock Component Rev-erb?[J]. Biochemical Pharmacology. 2020, 172: 113773.
Chen Q, Xin G, Li S, et al. Berberine-mediated REDD1 down-regulation ameliorates senescence of retinal pigment epithelium by interrupting the ROS-DDR positive feedback loop. Phytomedicine. 2022: 154181.
Zhu Y , Ma N , Li H , et al. Berberine induces apoptosis and DNA damage in MG-63 human osteosarcoma cells[J]. Molecular Medicine Reports, 2014, 10(4):1734-1738.
Liu J, Xu H, Zhang L, et al. Chronoefficacy of the herbal medicines Puerariae radix and Coptidis rhizoma in mice: A potential role of REV-ERB?[J]. bioRxiv. 2021
Liu J, Xu H, Zhang L, et al. Chronoefficacy of the herbal medicines Puerariae radix and Coptidis rhizoma in mice: A potential role of REV-ERB?. Frontiers in pharmacology. 2021: 1966.