IWP-O1

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TargetMol
Product Code: TAR-T5342
Supplier: TargetMol
CodeSizePrice
TAR-T5342-1mg1mg£100.00
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TAR-T5342-2mg2mg£114.00
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TAR-T5342-5mg5mg£148.00
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TAR-T5342-1mL1 mL * 10 mM (in DMSO)£156.00
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TAR-T5342-10mg10mg£209.00
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TAR-T5342-25mg25mg£367.00
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TAR-T5342-50mg50mg£511.00
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TAR-T5342-100mg100mg£703.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.
CAS:
2074607-48-8
Formula:
C26H20N6O
Molecular Weight:
432.487
Pathway:
Stem Cells; Cytoskeletal Signaling
Purity:
0.9998
SMILES:
O=C(Cn1nnc(c1-c1ccccc1)-c1ccncc1)Nc1ccc(cn1)-c1ccccc1
Target:
Wnt/beta-catenin; Porcupine

References

You L, et al. Development of a triazole class of highly potent Porcn inhibitors. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5891-5895.