JG-98

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TargetMol
Product Code: TAR-T5350
Supplier: TargetMol
CodeSizePrice
TAR-T5350-1mg1mg£152.00
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TAR-T5350-2mg2mg£189.00
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TAR-T5350-5mg5mg£282.00
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TAR-T5350-10mg10mg£410.00
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TAR-T5350-25mg25mg£622.00
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TAR-T5350-50mg50mg£858.00
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TAR-T5350-100mg100mg£1,139.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
JG-98 is an allosteric Hsp70 inhibitor, displays high active against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50s: 0.4/0.7 μM).
CAS:
1456551-16-8
Formula:
C24H21Cl2N3OS3
Molecular Weight:
534.53
Pathway:
Metabolism; Cytoskeletal Signaling; Apoptosis
Purity:
0.9935
SMILES:
[Cl-].CCn1c(=Cc2scc[n+]2Cc2ccccc2)sc(=C2Sc3cc(Cl)ccc3N2C)c1=O
Target:
Apoptosis; HSP

References

Li X, et al. Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer. Mol Cancer Ther. 2015 Mar;14(3):642-8. Li X, et al. Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents. ACS Med Chem Lett. 2013 Nov 14;4(11).