TargetMol

Oleandrin

Product Code:
 
TAR-T5S0890
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5S0890-1mg1mg£149.00
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TAR-T5S0890-2mg2mg£189.00
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TAR-T5S0890-5mg5mg£303.00
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TAR-T5S0890-1mL1 mL * 10 mM (in DMSO)£365.00
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TAR-T5S0890-10mg10mg£442.00
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TAR-T5S0890-25mg25mg£683.00
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TAR-T5S0890-50mg50mg£930.00
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TAR-T5S0890-100mg100mg£1,219.00
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TAR-T5S0890-500mg500mg£2,392.00
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Further Information

Bioactivity:
1. Oleandrin, the principal cardiac glycoside component of PBI-524, can quantitatively account for regulation of BDNF at both the protein and transcriptional levels. 2. Oleandrin are known to inhibit the Na, K-ATPase pump, resulting in a consequent increase in calcium influx in heart muscle. 3. Oleandrin has stronger anti-proliferative activity in undifferentiated CaCO-2 cells (IC50, 8.25 nM) , causes an autophagic cell death and altered ERK phosphorylation in undifferentiated.
CAS:
465-16-7
Formula:
C32H48O9
Molecular Weight:
576.727
Pathway:
Membrane transporter/Ion channel; Apoptosis
Purity:
0.9994
SMILES:
CO[C@H]1C[C@H](O[C@H]2CC[C@@]3(C)[C@H](CC[C@@H]4[C@@H]3CC[C@]3(C)[C@H]([C@H](C[C@]43O)OC(C)=O)C3=CC(=O)OC3)C2)O[C@@H](C)[C@@H]1O
Target:
Apoptosis; ATPase; Potassium Channel; Sodium Channel

References

Pan L, Zhang Y, Zhao W, et al. The cardiac glycoside oleandrin induces apoptosis in human colon cancer cells via the mitochondrial pathway[J]. Cancer Chemotherapy and Pharmacology. 2017 Jul;80(1):91-100. Raviprakash N , Manna S K . Short-term exposure to oleandrin enhances responses to IL-8 by increasing cell surface IL-8 receptors[J]. British Journal of Pharmacology, 2014, 171(14):3339-3351. Pan L, Zhang Y, Zhao W, et al. The cardiac glycoside oleandrin induces apoptosis in human colon cancer cells via the mitochondrial pathway. Cancer Chemotherapy and Pharmacology. 2017 Jul;80(1):91-100