Z-DEVD-FMK

TargetMol
Product Code: TAR-T6005
Supplier: TargetMol
CodeSizePrice
TAR-T6005-1mg1mg£112.00
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TAR-T6005-5mg5mg£188.00
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TAR-T6005-1mL1 mL * 10 mM (in DMSO)£244.00
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Quantity:
TAR-T6005-10mg10mg£268.00
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TAR-T6005-25mg25mg£405.00
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TAR-T6005-50mg50mg£548.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

1 / 1

Further Information

Bioactivity:
Z-DEVD-FMK is a selective, irreversible Caspase-3 inhibitor, and also exhibits effective inhibition activity on caspase-6, caspase-7, caspase-8, and caspase-10.
CAS:
210344-95-9
Formula:
C30H41FN4O12
Molecular Weight:
668.672
Pathway:
Apoptosis; Proteases/Proteasome
Purity:
0.9969
SMILES:
COC(=O)CC[C@H](NC(=O)[C@H](CC(=O)OC)NC(=O)OCc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)OC)C(=O)CF
Target:
Caspase

References

Wang J, et al. J Card Fail. 2000, 6(3), 243-249. Wang X Y, Wu K H, Pang H L, et al. Study on the Role of Cytc in Response to BmNPV Infection in Silkworm, Bombyx mori (Lepidoptera)[J]. International journal of molecular sciences. 2019, 20(18): 4325. Liu X, Song X, Luan D, et al. Real-time in situ Visualizing the Sequential Activation of Caspase Cascade Using a Multi-color Au-Se Bonding Fluorescent Nanoprobe[J]. Analytical chemistry. 2019 May 7;91(9):5994-6002. Kanthasamy AG, et al. Free Radic Biol Med. 2006, 41(10), 1578-1589. Zhang Y, Fan B Y, Pang Y L, et al. Neuroprotective effect of deferoxamine on erastin-induced ferroptosis in primary cortical neurons[J]. Neural regeneration research. 2020, 15(8): 1539. Meguro T, et al. Stroke. 2001, 32(2), 561-566. Zhao Q, Feng H, Yang Z, et al. The central role of a two?way positive feedback pathway in molecular targeted therapies?mediated pyroptosis in anaplastic thyroid cancer. Clinical and Translational Medicine. 2022, 12(2): e727 Zou Y, Zheng S, Xie X, et al. N6-methyladenosine regulated FGFR4 attenuates ferroptotic cell death in recalcitrant HER2-positive breast cancer. Nature Communications. 2022, 13(1): 1-18 Zhu Q, Ding L, Zi Z, et al. Viral-Mediated AURKB Cleavage Promotes Cell Segregation and Tumorigenesis. Cell Reports. 2019 Mar 26;26(13):3657-3671.e5 Zhang Y, Fan B Y, Pang Y L, et al. Neuroprotective effect of deferoxamine on erastininduced ferroptosis in primary cortical neurons. Neural Regeneration Research. 2020, 15(8): 1539 Zhao Q, Feng H, Yang Z, et al. The central role of a two?way positive feedback pathway in molecular targeted therapies?mediated pyroptosis in anaplastic thyroid cancer. Clinical and Translational Medicine. 2022, 12(2): e727 Rickers A, et al. Eur J Immunol. 1998, (1), 296-304. Xia H, Zhang Z, You F. Inhibiting ACSL1-Related Ferroptosis Restrains Murine Coronavirus Infection. Viruses. 2021, 13(12): 2383. Wang X Y, Wu K H, Pang H L, et al. Study on the Role of Cytc in Response to BmNPV Infection in Silkworm, Bombyx mori (Lepidoptera). International journal of molecular sciences. 2019, 20(18): 4325. Zhang Y, Fan B Y, Pang Y L, et al. Neuroprotective effect of deferoxamine on erastininduced ferroptosis in primary cortical neurons[J]. Neural Regeneration Research. 2020, 15(8): 1539. Liu X, Song X, Luan D, et al. Real-time in situ Visualizing the Sequential Activation of Caspase Cascade Using a Multi-color Au-Se Bonding Fluorescent Nanoprobe. Analytical Chemistry. 2019, 91(9): 5994-6002 Tang Q, Li W, Zheng X, et al. MELK is an oncogenic kinase essential for metastasis, mitotic progression, and programmed death in lung carcinoma. Signal Transduction and Targeted Therapy. 2020, 5(1): 1-12. Hussain M, Lu Y, Tariq M, et al. A small-molecule Skp1 inhibitor elicits cell death by p53-dependent mechanism. Iscience. 2022, 25(7): 104591. Zhu Q, Ding L, Zi Z, et al. Viral-Mediated AURKB Cleavage Promotes Cell Segregation and Tumorigenesis[J]. Cell reports. 2019 Mar 26;26(13):3657-3671.e5. Yakovlev AG, et al. J Neurosci. 1997, 17(19), 7415-7424.