GSK256066

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TargetMol
Product Code: TAR-T6054
Supplier: TargetMol
CodeSizePrice
TAR-T6054-1mg1mg£97.00
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TAR-T6054-2mg2mg£108.00
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TAR-T6054-5mg5mg£132.00
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Quantity:
TAR-T6054-1mL1 mL * 10 mM (in DMSO)£140.00
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TAR-T6054-10mg10mg£173.00
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TAR-T6054-25mg25mg£282.00
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TAR-T6054-50mg50mg£414.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.Phase 2.
CAS:
801312-28-7
Formula:
C27H26N4O5S
Molecular Weight:
518.59
Pathway:
Metabolism
Purity:
0.9966
SMILES:
COc1cccc(Nc2c(cnc3c(C)cc(cc23)S(=O)(=O)c2cccc(c2)C(=O)N(C)C)C(N)=O)c1
Target:
PDE

References

Nials AT, et al. J Pharmacol Exp Ther, 2011, 337(1), 137-144. Tralau-Stewart CJ, et al. J Pharmacol Exp Ther, 2011, 337(1), 145-154. Woodrow MD, et al. Bioorg Med Chem Lett, 2009, 19(17), 5261-5265.