A-674563

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TargetMol
Product Code: TAR-T6139
Supplier: TargetMol
CodeSizePrice
TAR-T6139-1mg1mg£173.00
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TAR-T6139-2mg2mg£238.00
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TAR-T6139-5mg5mg£326.00
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TAR-T6139-1mL1 mL * 10 mM (in DMSO)£383.00
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TAR-T6139-10mg10mg£511.00
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TAR-T6139-25mg25mg£905.00
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TAR-T6139-50mg50mg£1,402.00
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TAR-T6139-100mg100mg£2,318.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
CAS:
552325-73-2
Formula:
C22H22N4O
Molecular Weight:
358.445
Pathway:
PI3K/Akt/mTOR signaling; Cell Cycle/Checkpoint; MAPK; Cytoskeletal Signaling; Stem Cells; Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccccc2)c1
Target:
ERK; GSK-3; Akt; PKA; CDK

References

Zhu QS, et al, Cancer Res, 2008, 68(8), 2895-2903. Luo Y, et al, Mol Cancer Ther, 2005, 4(6), 977-986. Tatsuya Okuzumi, et al, Mol Biosyst, 2010, 6(8), 1389-1402.