Dolutegravir

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TargetMol
Product Code: TAR-T6198
Supplier: TargetMol
CodeSizePrice
TAR-T6198-1mg1mg£95.00
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TAR-T6198-2mg2mg£105.00
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TAR-T6198-1mL1 mL * 10 mM (in DMSO)£121.00
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TAR-T6198-5mg5mg£125.00
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TAR-T6198-10mg10mg£164.00
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TAR-T6198-25mg25mg£215.00
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TAR-T6198-50mg50mg£302.00
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TAR-T6198-100mg100mg£432.00
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TAR-T6198-200mg200mg£583.00
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TAR-T6198-500mg500mg£789.00
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TAR-T6198-1g1g£1,010.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Dolutegravir (IC50=2.7 nM), a two-metal-binding HIV integrase inhibitor, exhibits medium activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H.
CAS:
1051375-16-6
Formula:
C20H19F2N3O5
Molecular Weight:
419.385
Pathway:
Microbiology/Virology; Proteases/Proteasome
Purity:
0.9908
SMILES:
C[C@@H]1CCO[C@H]2Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c(O)c3C(=O)N12
Target:
HIV Protease

References

Herrmann A, Roesner M, Werner T, et al. Potent inhibition of HIV replication in primary human cells by novel synthetic polyketides inspired by Aureothin[J]. Scientific Reports. 2020, 10(1): 1-15. Charpentier C, et al. AIDS. 2010, 24(17), 2753-275 Herrmann A, Roesner M, Werner T, et al. Potent inhibition of HIV replication in primary human cells by novel synthetic polyketides inspired by Aureothin. Scientific Reports. 2020, 10(1): 1-15 Kobayashi M, et al. Antimicrob Agents Chemother. 2011, 55(2), 813-821. Moss L, et al. The comparative disposition and metabolism of dolutegravir, a potent HIV-1 integrase inhibitor, in mice, rats, and monkeys. Xenobiotica. 2015 Jan;45(1):60-70.