XL888

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TargetMol
Product Code: TAR-T6248
Supplier: TargetMol
CodeSizePrice
TAR-T6248-1mg1mg£105.00
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TAR-T6248-5mg5mg£177.00
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TAR-T6248-1mL1 mL * 10 mM (in DMSO)£189.00
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TAR-T6248-10mg10mg£245.00
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TAR-T6248-25mg25mg£389.00
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TAR-T6248-50mg50mg£550.00
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Quantity:
TAR-T6248-100mg100mg£768.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
XL888 is an ATP-competitive inhibitor of Hsp90 ( IC50: 24 nM). Heat shock protein 90 (Hsp90) is a chaperone that maintains the functionality of client proteins involved in cell proliferation, cell cycling, and apoptosis. Through this action, specific client proteins are degraded, resulting in cell cycle arrest or apoptosis. XL888 is orally bioavailable and shows efficacy in tumor regression in gastric carcinoma and melanoma xenografts in mice.
CAS:
1149705-71-4
Formula:
C29H37N5O3
Molecular Weight:
503.647
Pathway:
Cytoskeletal Signaling; Metabolism
Purity:
0.981
SMILES:
CC[C@@H](C)Nc1cc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3c2ccc(cn2)C(=O)C2CC2)c(C)cc1C(N)=O
Target:
HSP

References

Paraiso KH, et al. Clin Cancer Res, 2012, 18(9), 2502-2514. Bussenius J, et al. Bioorg Med Chem Lett, 2012, 22(17), 5396-5404.