Avagacestat

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TargetMol
Product Code: TAR-T6249
Supplier: TargetMol
CodeSizePrice
TAR-T6249-1mg1mg£116.00
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TAR-T6249-5mg5mg£169.00
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TAR-T6249-1mL1 mL * 10 mM (in DMSO)£185.00
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TAR-T6249-10mg10mg£261.00
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TAR-T6249-25mg25mg£426.00
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TAR-T6249-50mg50mg£599.00
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Quantity:
TAR-T6249-100mg100mg£824.00
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TAR-T6249-500mg500mg£1,589.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
Avagacestat (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.
CAS:
1146699-66-2
Formula:
C20H17ClF4N4O4S
Molecular Weight:
520.88
Pathway:
Neuroscience; Stem Cells; Proteases/Proteasome
Purity:
0.9887
SMILES:
NC(=O)[C@@H](CCC(F)(F)F)N(Cc1ccc(cc1F)-c1ncon1)S(=O)(=O)c1ccc(Cl)cc1
Target:
Gamma-secretase

References

Gillman KW, et al. Med Chem Lett, 2010, 1 (3), 120?124.