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TargetMol
Product Code: TAR-T6269
Supplier: TargetMol
CodeSizePrice
TAR-T6269-1mg1mg£98.00
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TAR-T6269-2mg2mg£109.00
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TAR-T6269-5mg5mg£134.00
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TAR-T6269-1mL1 mL * 10 mM (in DMSO)£145.00
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TAR-T6269-10mg10mg£189.00
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TAR-T6269-25mg25mg£250.00
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TAR-T6269-50mg50mg£302.00
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TAR-T6269-100mg100mg£464.00
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TAR-T6269-200mg200mg£596.00
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TAR-T6269-500mg500mg£871.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
R428 is a selective inhibitor of Axl (IC50: 14 nM) and has been investigated for the treatment of NSCLC.
CAS:
1037624-75-1
Formula:
C30H34N8
Molecular Weight:
506.64
Pathway:
Tyrosine Kinase/Adaptors
Purity:
0.998
SMILES:
Nc1nc(Nc2ccc3CC[C@@H](CCc3c2)N2CCCC2)nn1-c1cc2CCCc3ccccc3-c2nn1
Target:
TAM Receptor

References

Yuan Y, Guo Y, Guo Z W, et al.Marsdenia tenacissima extract induces endoplasmic reticulum stress-associated immunogenic cell death in non-small cell lung cancer cells through targeting AXL.Journal of Ethnopharmacology.2023: 116620. Lijnen HR, et al. Growth arrest-specific protein 6 receptor antagonism impairs adipocyte differentiation and adipose tissue development in mice. J Pharmacol Exp Ther. 2011 May;337(2):457-64. Ghosh AK, et al. The novel receptor tyrosine kinase Axl is constitutively active in B-cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases: implications for therapy. Blood. 2011 Feb 10;117(6):1928-37. Holland SJ, et al. R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer. Cancer Res. 2010 Feb 15;70(4):1544-54. Huang M, Liu M, Huang D, et al. Tumor perivascular cell-derived extracellular vesicles promote angiogenesis via the Gas6/Axl pathway. Cancer Letters. 2021