AMG-458

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TargetMol
Product Code: TAR-T6378
Supplier: TargetMol
CodeSizePrice
TAR-T6378-1mg1mg£121.00
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TAR-T6378-2mg2mg£149.00
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TAR-T6378-5mg5mg£209.00
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TAR-T6378-1mL1 mL * 10 mM (in DMSO)£222.00
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TAR-T6378-10mg10mg£275.00
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TAR-T6378-25mg25mg£462.00
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TAR-T6378-50mg50mg£642.00
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TAR-T6378-100mg100mg£863.00
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TAR-T6378-500mg500mg£1,661.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
AMG 458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells.
CAS:
913376-83-7
Formula:
C30H29N5O5
Molecular Weight:
539.592
Pathway:
Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Target:
c-Met/HGFR

References

Liu L, et al. J Med Chem, 2008, 51(13), 3688-3691. Torossian A, et al. Int J Radiat Oncol Biol Phys, 2012, 84(4), e525-531. Teffera Y, et al. Chem Res Toxicol, 2008, 21(11), 2216-2222.