EHT 1864

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TargetMol
Product Code: TAR-T6483
Supplier: TargetMol
CodeSizePrice
TAR-T6483-1mg1mg£102.00
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TAR-T6483-5mg5mg£138.00
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TAR-T6483-1mL1 mL * 10 mM (in DMSO)£158.00
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TAR-T6483-10mg10mg£181.00
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TAR-T6483-25mg25mg£290.00
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TAR-T6483-50mg50mg£470.00
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TAR-T6483-100mg100mg£642.00
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TAR-T6483-200mg200mg£860.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
EHT 1864 is a effective Rac family GTPase inhibitor for Rac1/Rac1b/Rac2/Rac3 (Kd: 40/50/60/250 nM).
CAS:
754240-09-0
Formula:
C25H29Cl2F3N2O4S
Molecular Weight:
581.47
Pathway:
Cell Cycle/Checkpoint; MAPK; GPCR/G Protein
Purity:
0.9942
SMILES:
Cl.Cl.FC(F)(F)c1ccc2c(SCCCCCOc3coc(CN4CCOCC4)cc3=O)ccnc2c1
Target:
Rho; Ras

References

Liu Y, Sun Y, Xu Y, et al.Targeting VPS41 induces methuosis and inhibits autophagy in cancer cells.Cell Chemical Biology.2023 Liu X, Wang S, Zheng H, et al. Epimedokoreanin C, A Prenylated Flavonoid Isolated from Epimedium Koreanum, Induces Non-Apoptotic Cell Death with the Characteristics of Methuosis in Lung Cancer Cells. American Journal of Cancer Research. 2021, 11(7): 3496. Shutes A, et al. J Biol Chem. 2007, 282(49), 35666-35678. Raynaud F, et al. J Biol Chem. 2014, 289(5), 2600-2609. Liu X, Wang S, Zheng H, et al. Epimedokoreanin C, A Prenylated Flavonoid Isolated from Epimedium Koreanum, Induces Non-Apoptotic Cell Death with the Characteristics of Methuosis in Lung Cancer Cells[J]. 2020 Weddle E A, K?seo?lu V K, DeVasure B A, et al. The type three secretion system effector protein IpgB1 promotes Shigella flexneri cell-to-cell spread through double-membrane vacuole escape. PLoS Pathogens. 2022, 18(2): e1010380 D?sir? L, et al. J Biol Chem. 2005, 280(45), 37516-3752