Xevinapant

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TargetMol
Product Code: TAR-T6763
Supplier: TargetMol
CodeSizePrice
TAR-T6763-1mg1mg£99.00
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TAR-T6763-2mg2mg£112.00
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TAR-T6763-5mg5mg£139.00
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TAR-T6763-10mg10mg£177.00
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TAR-T6763-1mL1 mL * 10 mM (in DMSO)£189.00
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TAR-T6763-25mg25mg£306.00
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TAR-T6763-50mg50mg£515.00
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TAR-T6763-100mg100mg£701.00
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TAR-T6763-500mg500mg£1,187.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
AT406 (SM-406, ARRY-334543) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1.
CAS:
1071992-99-8
Formula:
C32H43N5O4
Molecular Weight:
561.727
Pathway:
Apoptosis
Purity:
0.9977
SMILES:
CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)CC(C)C
Target:
IAP

References

Cai Q, et al. J Med Chem, 2011, 54(8), 2714-2726.