Endoxifen Z-isomer hydrochloride
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| TAR-T6827-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| TAR-T6827-50mg | 50mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Endoxifen HCl is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
CAS:
1032008-74-4
Formula:
C25H28ClNO2
Molecular Weight:
409.95
Pathway:
JAK/STAT signaling; Tyrosine Kinase/Adaptors; Endocrinology/Hormones; Membrane transporter/Ion channel; Angiogenesis
Purity:
0.98
SMILES:
Cl.CCC(=C(/c1ccc(O)cc1)c1ccc(OCCNC)cc1)c1ccccc1
Target:
Estrogen Receptor/ERR; Potassium Channel; Estrogen/progestogen Receptor; HER
References
Chae YJ, et al. Eur J Pharmacol. 2015, 752, 1-7.
Li J, Yu F, Guo H, et al. Crystal structure of plant PLD?1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D[J]. Cell Research. 2020, 30(1): 61-69.
Wu X, et al. Cancer Res. 2009, 69(5), 1722-1727.
Lim YC, et al. Cancer Chemother Pharmacol. 2005, 55(5), 471-478.
Ahmad A, et al. Breast Cancer Res Treat. 2010, 122(2), 579-584.
Ali SM, et al. Bioorg Med Chem Lett. 2010, 20(8), 2665-2667.
Wang K, Chen Y, Gao S, et al. Norlichexanthone purified from plant endophyte prevents postmenopausal osteoporosis by targeting ER? to inhibit RANKL signaling[J]. Acta Pharmaceutica Sinica B. 2020
Li J, Yu F, Guo H, et al. Crystal structure of plant PLD?1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D. Cell Research. 2020, 30(1): 61-69.