PD168393

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TargetMol
Product Code: TAR-T6932
Supplier: TargetMol
CodeSizePrice
TAR-T6932-1mg1mg£97.00
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TAR-T6932-2mg2mg£107.00
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TAR-T6932-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T6932-5mg5mg£119.00
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TAR-T6932-10mg10mg£144.00
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TAR-T6932-25mg25mg£197.00
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TAR-T6932-50mg50mg£258.00
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TAR-T6932-100mg100mg£333.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.
CAS:
194423-15-9
Formula:
C17H13BrN4O
Molecular Weight:
369.222
Pathway:
JAK/STAT signaling; Chromatin/Epigenetic; Cytoskeletal Signaling; Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors; Autophagy
Purity:
0.997
SMILES:
Brc1cccc(Nc2ncnc3ccc(NC(=O)C=C)cc23)c1
Target:
Apoptosis; EGFR; FGFR; IGF-1R; PDGFR; PKC; Autophagy

References

Bose R, et al. Proc Natl Acad Sci U S A, 2006, 103(26), 9773-9778. Fry W, et al. Proc Natl Acad Sci U S A. 1998, 95(20), 12022-12027.