TargetMol

Protosappanin B

Product Code:
 
TAR-T6S1780
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6S1780-5mg5mg£124.00
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TAR-T6S1780-1mL1 mL * 10 mM (in DMSO)£132.00
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TAR-T6S1780-10mg10mg£164.00
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TAR-T6S1780-25mg25mg£227.00
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Further Information

Bioactivity:
1. Protosappanin B significantly increases cell viability, inhibits cell apoptosis and up-regulates the expression of growth-associated protein 43. 2. Protosappanin B induces the degradation of p53 protein, via activation of a MDM2-dependent ubiquitination process.
CAS:
102036-29-3
Formula:
C16H16O6
Molecular Weight:
304.298
Pathway:
Apoptosis
Purity:
0.9886
SMILES:
OC[C@]1(O)COc2cc(O)ccc2-c2cc(O)c(O)cc2C1
Target:
Apoptosis

References

Pyun B J, Jo K, Lee J Y, et al. Caesalpinia sappan Linn. Ameliorates Allergic Nasal Inflammation by Upregulating the Keap1/Nrf2/HO-1 Pathway in an Allergic Rhinitis Mouse Model and Nasal Epithelial Cells. Antioxidants. 2022, 11(11): 2256. Zeng K W , Liao L X , Zhao M B , et al. Protosappanin B protects PC12 cells against oxygen?glucose deprivation-induced neuronal death by maintaining mitochondrial homeostasis via induction of ubiquitin-dependent p53 protein degradation[J]. European Journal of Pharmacology, 2015, 751:13-23.