TargetMol

Mavacamten

Product Code:
 
TAR-T7134
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7134-1mg1mg£115.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T7134-5mg5mg£148.00
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TAR-T7134-10mg10mg£177.00
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Quantity:
TAR-T7134-1mL1 mL * 10 mM (in DMSO)£209.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T7134-25mg25mg£288.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T7134-50mg50mg£432.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T7134-100mg100mg£598.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
MYK-461 is an orally bioavailable inhibitor of cardiac myosin ATPase,( IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively)
CAS:
1642288-47-8
Formula:
C15H19N3O2
Molecular Weight:
273.336
Pathway:
Cytoskeletal Signaling
Purity:
0.98
SMILES:
CC(C)n1c(=O)cc(NC(C)c2ccccc2)[nH]c1=O
Target:
Myosin

References

Stern J A , Markova S , Ueda Y , et al. A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy[J]. Plos One, 2016, 11(12):e0168407. Kawas R F , Anderson R L , Ingle S R B , et al. A small molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle[J]. Journal of Biological Chemistry, 2017, 292(40):jbc.M117.776815.