6H05 (TFA)

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TargetMol
Product Code: TAR-T7326
Supplier: TargetMol
CodeSizePrice
TAR-T7326-1mg1mg£121.00
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TAR-T7326-2mg2mg£140.00
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TAR-T7326-5mg5mg£180.00
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TAR-T7326-1mL1 mL * 10 mM (in DMSO)£213.00
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TAR-T7326-10mg10mg£265.00
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TAR-T7326-25mg25mg£389.00
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TAR-T7326-50mg50mg£551.00
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TAR-T7326-100mg100mg£752.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
6H05 TFA is a selective, and allosteric oncogenic mutant K-Ras(G12C) inhibitor.
CAS:
2061344-88-3
Formula:
C22H31ClF3N3O4S3
Molecular Weight:
590.13
Pathway:
GPCR/G Protein; MAPK
Purity:
0.98
SMILES:
OC(=O)C(F)(F)F.CN(C)CCSSCCNC(=O)C1CCN(CC1)C(=O)CSc1ccc(Cl)cc1
Target:
Ras

References

Ostrem J M , Peters U , Sos M L , et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions[J]. Nature, 2013, 503(7477):548-551. Lu S , Li S , Zhang J . Harnessing Allostery: A Novel Approach to Drug Discovery[J]. Medicinal Research Reviews, 2014, 34(6):1242-1285.