Remdesivir

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TargetMol
Product Code: TAR-T7766
Supplier: TargetMol
CodeSizePrice
TAR-T7766-1mg1mg£168.00
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TAR-T7766-5mg5mg£343.00
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TAR-T7766-1mL1 mL * 10 mM (in DMSO)£432.00
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TAR-T7766-10mg10mg£502.00
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TAR-T7766-25mg25mg£711.00
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TAR-T7766-50mg50mg£970.00
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TAR-T7766-100mg100mg£1,283.00
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TAR-T7766-200mg200mg£1,669.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Remdesivir is a nucleoside analogue, with effective antiviral activity( EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells)
CAS:
1809249-37-3
Formula:
C27H35N6O8P
Molecular Weight:
602.585
Pathway:
DNA Damage/DNA Repair; Cell Cycle/Checkpoint; Microbiology/Virology
Purity:
0.9993
SMILES:
CCC(CC)COC(=O)C(C)NP(=O)(OCC1OC(C#N)(C(O)C1O)c1ccc2c(N)ncnn12)Oc1ccccc1
Target:
SARS-CoV; DNA/RNA Synthesis

References

Yousefi M, Lee W S, Chan W O Y, et al.Betacoronaviruses SARS-CoV-2 and HCoV-OC43 Infections in IGROV-1 Cell Line Require Aryl Hydrocarbon Receptor.Emerging Microbes & Infections.2023 (just-accepted): 2256416. Chen Y, Guo Y, Li S, et al.Remdesivir inhibits the progression of glioblastoma by enhancing endoplasmic reticulum stress.Biomedicine & Pharmacotherapy.2023, 157: 114037. Nicholson M W, Huang C Y, Wang J Y, et al. Cardio-and Neurotoxicity of Selected Anti-COVID-19 Drugs. Pharmaceuticals. 2022, 15(6): 765 Li Y, Cao L, Li G, et al. Remdesivir Metabolite GS-441524 Efficiently Inhibits SARS-CoV-2 Infection in Mouse Model[J] . Journal of medicinal chemistry. 2020 Li, Quanjie, et al Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase.. Acta Pharmaceutica Sinica B. (2021). Agostini M L , Andres E L , Sims A C , et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease[J]. Mbio, 2018, 9(2):e00221-18. Zhao J, Liu Q, Yi D, et al. 5-Iodotubercidin inhibits SARS-CoV-2 RNA synthesis. Antiviral Research. 2022: 105254. Nguyenla X, Wehri E, Van Dis E, et al. Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells[J]. bioRxiv. 2020 Williams C G, Jureka A S, Silvas J A, et al. Inhibitors of VPS34 and fatty-acid metabolism suppress SARS-CoV-2 replication. Cell Reports. 2021: 109479. Silvas J A, Jureka A S, Nicolini A M, et al. Inhibitors of VPS34 and lipid metabolism suppress SARS-CoV-2 replication[J]. bioRxiv. 2020. Zhao J, Liu Q, Yi D, et al. 5-Iodotubercidin inhibits SARS-CoV-2 RNA synthesis. Antiviral Research. 2022: 105254. Wang M , Cao R , Zhang L , et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro[J]. cell research. Nguyenla X, Wehri E, Van Dis E, et al. Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells. Scientific Reports. 2022 Nov 2;12(1):18506. Li Y, Cao L, Li G, et al. Remdesivir Metabolite GS-441524 Efficiently Inhibits SARS-CoV-2 Infection in Mouse Model. Journal of Medicinal Chemistry. 2020