5'-Fluoroindirubinoxime

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TargetMol
Product Code: TAR-T8317
Supplier: TargetMol
CodeSizePrice
TAR-T8317-1mg1mg£129.00
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TAR-T8317-2mg2mg£156.00
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TAR-T8317-5mg5mg£209.00
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TAR-T8317-1mL1 mL * 10 mM (in DMSO)£228.00
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TAR-T8317-10mg10mg£303.00
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TAR-T8317-25mg25mg£372.00
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TAR-T8317-50mg50mg£436.00
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TAR-T8317-100mg100mg£598.00
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Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
5'-Fluoroindirubinoxime is a potent FLT3 inhibitor( IC50 : 15 nM).
CAS:
861214-33-7
Formula:
C16H10FN3O2
Molecular Weight:
295.273
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors
Purity:
1
SMILES:
Oc1[nH]c2ccc(F)cc2c1-c1[nH]c2ccccc2c1N=O
Target:
FLT

References

Choi SJ, et al. Indirubin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells. Bioorg Med Chem Lett. 2010 Mar 15;20(6):2033-7. Kim SA, et al. Antitumor activity of novel indirubin derivatives in rat tumor model. Clin Cancer Res. 2007 Jan 1;13(1):253-9.