NEO2734

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TargetMol
Product Code: TAR-T8658
Supplier: TargetMol
CodeSizePrice
TAR-T8658-1mg1mg£164.00
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TAR-T8658-5mg5mg£303.00
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TAR-T8658-1mL1 mL * 10 mM (in DMSO)£326.00
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TAR-T8658-10mg10mg£454.00
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TAR-T8658-25mg25mg£704.00
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TAR-T8658-50mg50mg£938.00
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TAR-T8658-100mg100mg£1,259.00
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TAR-T8658-500mg500mg£2,456.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
NEO2734 is an orally active and selective inhibitor of p300/CBP and BET bromodomain(IC50 of <30 nM for both p300/CBP and BET bromodomains).
CAS:
2081072-29-7
Formula:
C22H24F3N3O3
Molecular Weight:
435.447
Pathway:
Chromatin/Epigenetic
Purity:
0.9856
SMILES:
Cc1cc(cn(C)c1=O)-c1ccc2nc(C3CCOCC3)n(CCOC(F)(F)F)c2c1
Target:
Epigenetic Reader Domain; Histone Acetyltransferase

References

Chevaun D Morrison-Smit, et al. Combined Targeting of the BRD4-NUT-p300 Axis in NUT Midline Carcinoma by Dual Selective Bromodomain Inhibitor, NEO2734. Mol Cancer Ther. 2020 Jul;19(7):1406-1414. The novel BET-CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild-type prostate cancer