G5-7

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TargetMol
Product Code: TAR-T8742
Supplier: TargetMol
CodeSizePrice
TAR-T8742-1mg1mg£132.00
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TAR-T8742-5mg5mg£201.00
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TAR-T8742-1mL1 mL * 10 mM (in DMSO)£213.00
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TAR-T8742-10mg10mg£269.00
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TAR-T8742-25mg25mg£436.00
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TAR-T8742-50mg50mg£598.00
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TAR-T8742-100mg100mg£808.00
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TAR-T8742-500mg500mg£1,540.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
JAK2 inhibitor G5-7 is an orally active JAK2 inhibitor, selectively inhibits JAK2?mediated phosphorylation and activation of EGFR (Tyr1068) and STAT3 by binding to JAK2. G5-7 has the potential for glioma study
CAS:
939681-36-4
Formula:
C22H19F2NO3
Molecular Weight:
383.395
Pathway:
Stem Cells; Angiogenesis; JAK/STAT signaling; Apoptosis; Chromatin/Epigenetic
Purity:
0.9937
SMILES:
CCOC(=O)N1CC(=C/c2ccccc2F)C(=O)C(C1)=Cc1ccccc1F
Target:
Apoptosis; JAK

References

Kunyan He, et al. Blockade of glioma proliferation through allosteric inhibition of JAK2. Sci Signal. 2013 Jul 9;6(283):ra55.