ML266

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TargetMol
Product Code: TAR-T8990
Supplier: TargetMol
CodeSizePrice
TAR-T8990-1mg1mg£109.00
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TAR-T8990-2mg2mg£125.00
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TAR-T8990-5mg5mg£161.00
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TAR-T8990-1mL1 mL * 10 mM (in DMSO)£169.00
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TAR-T8990-10mg10mg£213.00
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TAR-T8990-25mg25mg£361.00
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TAR-T8990-50mg50mg£470.00
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TAR-T8990-100mg100mg£653.00
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TAR-T8990-500mg500mg£1,291.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
ML266 is glucocerebrosidase (GCase) molecule chaperone, IC50 = 2.5 ?M. ML266 binds to GCase and transports of the mutant protein to the lysosome, and resume the activity of GCase. ML266 dose not inhibit the GCase enzyme?s action. ML266 has the potential for the research of gaucher disease.
CAS:
1462267-08-8
Formula:
C24H22BrN3O4
Molecular Weight:
496.35
Pathway:
Metabolism
Purity:
0.9845
SMILES:
O=C(NCC(=O)N(C=1C=CC=CC1)C)C=2C=CC=CC2OCC(=O)NC3=CC=C(Br)C=C3
Target:
Glucokinase

References

Rogers S, et al. Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase. 2012 Mar 27 [updated 2013 Mar 7].