Necrostatin-34

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TargetMol
Product Code: TAR-T9095
Supplier: TargetMol
CodeSizePrice
TAR-T9095-1mg1mg£135.00
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TAR-T9095-5mg5mg£229.00
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TAR-T9095-1mL1 mL * 10 mM (in DMSO)£254.00
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TAR-T9095-10mg10mg£303.00
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TAR-T9095-25mg25mg£502.00
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TAR-T9095-50mg50mg£693.00
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TAR-T9095-100mg100mg£938.00
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TAR-T9095-500mg500mg£1,813.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
Necrostatin-34 is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain.
CAS:
375835-43-1
Formula:
C18H16N4O2S2
Molecular Weight:
384.48
Pathway:
NF-κb; Apoptosis
Purity:
0.9847
SMILES:
O=C(NC1=NC=CS1)CSC2=C(C#N)C(C3=CC=C(C)C=C3)CC(N2)=O
Target:
RIP kinase

References

Huyan Meng, et al. Discovery of a cooperative mode of inhibiting RIPK1 kinase. Cell Discov. 2021 Jun 1;7(1):41.