XL177A

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TargetMol
Product Code: TAR-T9122
Supplier: TargetMol
CodeSizePrice
TAR-T9122-1mg1mg£148.00
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TAR-T9122-5mg5mg£229.00
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TAR-T9122-1mL1 mL * 10 mM (in DMSO)£309.00
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TAR-T9122-10mg10mg£322.00
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TAR-T9122-25mg25mg£499.00
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TAR-T9122-50mg50mg£687.00
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TAR-T9122-100mg100mg£938.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.
CAS:
2417089-74-6
Formula:
C48H57ClN8O5
Molecular Weight:
861.49
Pathway:
DNA Damage/DNA Repair; Ubiquitination; Cell Cycle/Checkpoint
Purity:
0.9875
SMILES:
CN1CCN(CCC(=O)Nc2ccc3c(c2)ncn(CC2(O)CCN(CC2)C(=O)[C@@H](CCCNC(=O)c2ccc4c(Cl)c5CCCCc5nc4c2)Cc2ccccc2)c3=O)CC1
Target:
DUB

References

Nathan J Schauer, et al. Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism. Sci Rep.2020 Mar 24;10(1):5324.