TargetMol

4-hydroxyestrone-4-methyl ether

Product Code:
 
TAR-T9455
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T9455-1mg1mg£328.00
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Further Information

Bioactivity:
4-hydroxyestrone-4-methyl ether is the methylation of 4-OHE1, which is catalyzed by COMT.
CAS:
58562-33-7
Formula:
C38H47O6
Molecular Weight:
599.78
Pathway:
Metabolism; Endocrinology/Hormones
Purity:
0.98
SMILES:
C[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1c(cc1)c3c(OC)c1O)C2=OC[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1c(cc1)c3c(OC)c1O)C2=O
Target:
Estrogen Receptor/ERR; Endogenous Metabolite

References

Lippert C, et al. The effects of A-ring and D-ring metabolites of estradiol on the proliferation of vascular endothelial cells. Life Sci. 2000 Aug 18;67(13):1653-8. Emons G, et al. Radioimmunoassay for 4-hydroxyestrone 4-methyl ether in human urine. Horm Metab Res. 1982 Jul;14(7):376-9. Dawling S, et al. Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: comparison of wild-type and variant COMT isoforms. Cancer Res. 2001 Sep 15;61(18):6716-22.